In the event of a radiological event, radionuclides
are feared as they will persist in the food chain and environment.
Consumption of water and food will lead to internal exposure,
leading to additional radiation exposure over time. We aim to
understand the differences between internal and external exposure
in terms of biomarker identification and metabolic pathways that
are altered. The first study in collaboration with Lovelace Respiratory
Research Institute focused on internal exposure to 137Cs. The
study lasted for 30 days and mice received cumulative doses between
1.95 and 9.91 Gy (time dependent exposure). As highlighted in
the multidimensional scaling plot, the overall metabolic profiles
lead to clustering of control versus treated mice in two distinct
The differences between external and internal gamma exposure regarding urinary marker identification are highlighted in the table.
Development of urinary biomarkers for internal
exposure by cesium-137 using a metabolomics approach in mice.
Goudarzi M1, Weber W, Mak TD, Chung J, Doyle-Eisele M, Melo D,
Brenner DJ, Guilmette RA, Fornace AJ. Radiat Res. (2014)
Comparison between urinary markers of external and internal exposure with gamma radiation